Drug interactions
Dichlorphenamide + Insulin glargine
Severity: Moderate
Dichlorphenamide and Insulin glargine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can lower serum potassium, so combined use may cause clinically significant hypokalemia. Dichlorphenamide also causes metabolic acidosis and may affect glycemic management.
What this interaction means in plain words
Dichlorphenamide and Insulin glargine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Insulin glargine belongs to Endocrine.
Why it happens
Additive hypokalemia: insulin drives potassium into cells while dichlorphenamide increases renal potassium loss through carbonic anhydrase inhibition.
What to do
Monitor serum potassium and bicarbonate regularly and replace potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Insulin glargine?
MediHelp rates the interaction as moderate. Dichlorphenamide and Insulin glargine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can lower serum potassium, so combined use may cause clinically significant hypokalemia. Dichlorphenamide also causes metabolic acidosis and may affect glycemic management.
How serious is the interaction between Dichlorphenamide and Insulin glargine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and bicarbonate regularly and replace potassium as needed.
What other medicines interact with Insulin glargine?
MediHelp also lists interactions of Insulin glargine with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin glargine page.
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