Drug interactions
Dichlorphenamide + Liposomal doxorubicin
Severity: Moderate
Dichlorphenamide and Liposomal doxorubicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide causes renal potassium loss and metabolic acidosis. Doxorubicin patients with vomiting or diarrhea may also lose potassium, and hypokalemia increases arrhythmia risk in those with anthracycline cardiotoxicity.
What this interaction means in plain words
Dichlorphenamide and Liposomal doxorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Liposomal doxorubicin belongs to Oncology.
Why it happens
Additive hypokalemia, mainly from carbonic anhydrase inhibition causing renal potassium wasting.
What to do
Monitor serum potassium and bicarbonate regularly. Supplement potassium as needed, particularly in patients with cardiac disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Liposomal doxorubicin
- Dengue vaccine + Liposomal doxorubicin Contraindicated
- Belatacept + Liposomal doxorubicin Major
- Cyclosporine + Liposomal doxorubicin Major
- Dronedarone + Liposomal doxorubicin Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Liposomal doxorubicin Major
- Fingolimod + Liposomal doxorubicin Major
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Liposomal doxorubicin?
MediHelp rates the interaction as moderate. Dichlorphenamide and Liposomal doxorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide causes renal potassium loss and metabolic acidosis. Doxorubicin patients with vomiting or diarrhea may also lose potassium, and hypokalemia increases arrhythmia risk in those with anthracycline cardiotoxicity.
How serious is the interaction between Dichlorphenamide and Liposomal doxorubicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and bicarbonate regularly. Supplement potassium as needed, particularly in patients with cardiac disease.
What other medicines interact with Liposomal doxorubicin?
MediHelp also lists interactions of Liposomal doxorubicin with, for example, Dengue vaccine, Belatacept, Cyclosporine. The full list is on the Liposomal doxorubicin page.
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