Drug interactions
Dichlorphenamide + Midazolam
Severity: Moderate
Dichlorphenamide and Midazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide can cause somnolence, confusion and fatigue, which may add to midazolam sedation. The combination could deepen CNS depression.
What this interaction means in plain words
Dichlorphenamide and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Midazolam belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects; dichlorphenamide causes neurologic adverse effects through carbonic anhydrase inhibition.
What to do
Use the lowest effective midazolam dose and monitor sedation and respiratory status.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Midazolam?
MediHelp rates the interaction as moderate. Dichlorphenamide and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide can cause somnolence, confusion and fatigue, which may add to midazolam sedation. The combination could deepen CNS depression.
How serious is the interaction between Dichlorphenamide and Midazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective midazolam dose and monitor sedation and respiratory status.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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