Drug interactions
Dichlorphenamide + Moxifloxacin
Severity: Moderate
Dichlorphenamide and Moxifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide commonly causes hypokalemia, and low potassium predisposes to QT prolongation and torsades de pointes with moxifloxacin. The combination therefore raises arrhythmia risk indirectly.
What this interaction means in plain words
Dichlorphenamide and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Moxifloxacin belongs to Anti Bacterial.
Why it happens
Carbonic anhydrase inhibition causes renal potassium loss, and hypokalemia augments the QT-prolonging effect of moxifloxacin.
What to do
Check serum potassium and magnesium before and during therapy and replace deficits. Obtain an ECG if other QT risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Moxifloxacin?
MediHelp rates the interaction as moderate. Dichlorphenamide and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide commonly causes hypokalemia, and low potassium predisposes to QT prolongation and torsades de pointes with moxifloxacin. The combination therefore raises arrhythmia risk indirectly.
How serious is the interaction between Dichlorphenamide and Moxifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and magnesium before and during therapy and replace deficits. Obtain an ECG if other QT risk factors are present.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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