Drug interactions
Dichlorphenamide + Omeprazole
Severity: Moderate
Dichlorphenamide and Omeprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide causes renal potassium loss, and long-term proton pump inhibitor use can occasionally lower magnesium and secondarily potassium. Combined use may increase the risk of hypokalemia and related arrhythmias.
What this interaction means in plain words
Dichlorphenamide and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Omeprazole belongs to Gastrointestinal Tract.
Why it happens
Additive potassium-lowering effects: carbonic anhydrase inhibition increases renal potassium excretion, while PPI-related hypomagnesemia can impair potassium homeostasis.
What to do
Check serum potassium and magnesium at baseline and periodically during combined therapy. Replace electrolytes as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dichlorphenamide and Omeprazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Omeprazole?
MediHelp rates the interaction as moderate. Dichlorphenamide and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide causes renal potassium loss, and long-term proton pump inhibitor use can occasionally lower magnesium and secondarily potassium. Combined use may increase the risk of hypokalemia and related arrhythmias.
How serious is the interaction between Dichlorphenamide and Omeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and magnesium at baseline and periodically during combined therapy. Replace electrolytes as needed.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
