Drug interactions
Dichlorphenamide + Sirolimus
Severity: Moderate
Dichlorphenamide and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide commonly causes hypokalemia and metabolic acidosis, and sirolimus can disturb electrolytes including potassium and magnesium. Combined use may increase the risk of electrolyte disturbances.
What this interaction means in plain words
Dichlorphenamide and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Sirolimus belongs to Miscellaneous.
Why it happens
Additive potassium-lowering effects: carbonic anhydrase inhibition with renal potassium wasting plus sirolimus-associated electrolyte disturbance.
What to do
Monitor serum potassium, bicarbonate and magnesium at baseline and periodically; replace potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Sirolimus?
MediHelp rates the interaction as moderate. Dichlorphenamide and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide commonly causes hypokalemia and metabolic acidosis, and sirolimus can disturb electrolytes including potassium and magnesium. Combined use may increase the risk of electrolyte disturbances.
How serious is the interaction between Dichlorphenamide and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, bicarbonate and magnesium at baseline and periodically; replace potassium as needed.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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