Drug interactions
Dichlorphenamide + Tacrolimus
Severity: Moderate
Dichlorphenamide and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide causes potassium loss and metabolic acidosis, and tacrolimus can cause hyperkalemia and acidosis through renal effects. Combined use may produce unpredictable electrolyte and acid-base disturbances.
What this interaction means in plain words
Dichlorphenamide and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Tacrolimus belongs to Miscellaneous.
Why it happens
Additive pharmacodynamic effects on potassium and acid-base balance.
What to do
Monitor serum potassium and bicarbonate regularly. Adjust therapy if significant acidosis or electrolyte abnormalities develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Tacrolimus?
MediHelp rates the interaction as moderate. Dichlorphenamide and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide causes potassium loss and metabolic acidosis, and tacrolimus can cause hyperkalemia and acidosis through renal effects. Combined use may produce unpredictable electrolyte and acid-base disturbances.
How serious is the interaction between Dichlorphenamide and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and bicarbonate regularly. Adjust therapy if significant acidosis or electrolyte abnormalities develop.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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