Drug interactions
Dichlorphenamide + Voriconazole
Severity: Moderate
Dichlorphenamide and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can lower serum potassium, so hypokalemia may be more pronounced when they are combined. Low potassium increases the risk of weakness and arrhythmias, and voriconazole adds QT liability.
What this interaction means in plain words
Dichlorphenamide and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Voriconazole belongs to Anti Fungals.
Why it happens
Additive potassium-lowering effects; dichlorphenamide causes renal potassium loss and voriconazole is associated with hypokalemia.
What to do
Monitor serum potassium and bicarbonate at baseline and periodically. Replace potassium as needed and consider an ECG if levels are low.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Voriconazole?
MediHelp rates the interaction as moderate. Dichlorphenamide and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can lower serum potassium, so hypokalemia may be more pronounced when they are combined. Low potassium increases the risk of weakness and arrhythmias, and voriconazole adds QT liability.
How serious is the interaction between Dichlorphenamide and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and bicarbonate at baseline and periodically. Replace potassium as needed and consider an ECG if levels are low.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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