Drug interactions
Dichlorphenamide + Vorinostat
Severity: Moderate
Dichlorphenamide and Vorinostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vorinostat can cause hypokalemia, diarrhea and QT changes, and dichlorphenamide also lowers potassium. Combined use may increase electrolyte depletion and arrhythmia risk.
What this interaction means in plain words
Dichlorphenamide and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Vorinostat belongs to Oncology.
Why it happens
Additive hypokalemia from renal potassium loss and vorinostat-related electrolyte disturbance.
What to do
Monitor potassium and magnesium regularly and replace deficits. Consider ECG monitoring in patients with cardiac risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dichlorphenamide
Other interactions of Vorinostat
- Thioridazine + Vorinostat Contraindicated
- Amiodarone + Vorinostat Major
- Amisulpride + Vorinostat Major
- Anagrelide + Vorinostat Major
- Asenapine + Vorinostat Major
- Chlorpromazine + Vorinostat Major
Frequently asked questions
Can I take Dichlorphenamide with Vorinostat?
MediHelp rates the interaction as moderate. Dichlorphenamide and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vorinostat can cause hypokalemia, diarrhea and QT changes, and dichlorphenamide also lowers potassium. Combined use may increase electrolyte depletion and arrhythmia risk.
How serious is the interaction between Dichlorphenamide and Vorinostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor potassium and magnesium regularly and replace deficits. Consider ECG monitoring in patients with cardiac risk factors.
What other medicines interact with Dichlorphenamide?
MediHelp also lists interactions of Dichlorphenamide with, for example, Acetazolamide, Acetylsalicylic acid, Ammonium chloride. The full list is on the Dichlorphenamide page.
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