Drug interactions
Diclofenac + Drospirenone
Severity: Moderate
Diclofenac and Drospirenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has anti-mineralocorticoid activity and can raise serum potassium, and NSAIDs may add to this by reducing renal potassium excretion. Hyperkalemia is more likely in patients with renal impairment or on other potassium-raising drugs.
What this interaction means in plain words
Diclofenac and Drospirenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diclofenac belongs to Musculoskeletal; Drospirenone belongs to Endocrine.
Why it happens
Additive potassium retention from aldosterone antagonism by drospirenone and prostaglandin inhibition by NSAIDs.
What to do
In high-risk patients check serum potassium during the first cycle of concurrent use; avoid chronic daily NSAID use where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Drospirenone
Frequently asked questions
Can I take Diclofenac with Drospirenone?
MediHelp rates the interaction as moderate. Diclofenac and Drospirenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone has anti-mineralocorticoid activity and can raise serum potassium, and NSAIDs may add to this by reducing renal potassium excretion. Hyperkalemia is more likely in patients with renal impairment or on other potassium-raising drugs.
How serious is the interaction between Diclofenac and Drospirenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: In high-risk patients check serum potassium during the first cycle of concurrent use; avoid chronic daily NSAID use where possible.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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