Drug interactions
Diclofenac + Epoprostenol
Severity: Moderate
Diclofenac and Epoprostenol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epoprostenol is a potent platelet aggregation inhibitor and may increase bleeding risk when combined with NSAIDs that also impair platelet function. Diclofenac also adds gastrointestinal bleeding risk.
What this interaction means in plain words
Diclofenac and Epoprostenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diclofenac belongs to Musculoskeletal; Epoprostenol belongs to Genitourinary.
Why it happens
Additive antiplatelet effect: prostacyclin-mediated platelet inhibition plus NSAID cyclooxygenase inhibition.
What to do
Monitor for bleeding signs and avoid unnecessary NSAID use. Consider gastroprotection if the combination is required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Epoprostenol
- Acetylsalicylic acid + Epoprostenol Moderate
- Aescin + Epoprostenol Moderate
- Aldesleukin + Epoprostenol Moderate
- Alteplase + Epoprostenol Moderate
- Amlodipine-benazepril + Epoprostenol Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Epoprostenol Moderate
Frequently asked questions
Can I take Diclofenac with Epoprostenol?
MediHelp rates the interaction as moderate. Diclofenac and Epoprostenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epoprostenol is a potent platelet aggregation inhibitor and may increase bleeding risk when combined with NSAIDs that also impair platelet function. Diclofenac also adds gastrointestinal bleeding risk.
How serious is the interaction between Diclofenac and Epoprostenol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding signs and avoid unnecessary NSAID use. Consider gastroprotection if the combination is required.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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