Drug interactions
Diclofenac + Fludrocortisone
Severity: Moderate
Diclofenac and Fludrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fludrocortisone is a corticosteroid and, with diclofenac, may increase the risk of gastric ulceration and bleeding. Both drugs also promote fluid retention, which may worsen blood pressure or edema.
What this interaction means in plain words
Diclofenac and Fludrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diclofenac belongs to Musculoskeletal; Fludrocortisone belongs to Endocrine.
Why it happens
Additive gastrointestinal mucosal injury and sodium and fluid retention.
What to do
Use the lowest effective diclofenac dose for the shortest time and consider gastroprotection. Monitor blood pressure, edema and potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Diclofenac with Fludrocortisone?
MediHelp rates the interaction as moderate. Diclofenac and Fludrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fludrocortisone is a corticosteroid and, with diclofenac, may increase the risk of gastric ulceration and bleeding. Both drugs also promote fluid retention, which may worsen blood pressure or edema.
How serious is the interaction between Diclofenac and Fludrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective diclofenac dose for the shortest time and consider gastroprotection. Monitor blood pressure, edema and potassium.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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