Drug interactions
Diclofenac + Glipizide-metformin
Severity: Moderate
Diclofenac and Glipizide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may enhance sulfonylurea effects and cause hypoglycemia, although diclofenac has less protein-binding effect than some others. NSAIDs can also impair renal function, which raises metformin accumulation risk.
What this interaction means in plain words
Diclofenac and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diclofenac belongs to Musculoskeletal; Glipizide-metformin belongs to Endocrine.
Why it happens
Possible displacement from protein binding or reduced clearance, plus NSAID-induced renal impairment affecting metformin elimination.
What to do
Monitor blood glucose and renal function with regular NSAID use. Use the lowest effective NSAID dose and shortest duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Frequently asked questions
Can I take Diclofenac with Glipizide-metformin?
MediHelp rates the interaction as moderate. Diclofenac and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may enhance sulfonylurea effects and cause hypoglycemia, although diclofenac has less protein-binding effect than some others. NSAIDs can also impair renal function, which raises metformin accumulation risk.
How serious is the interaction between Diclofenac and Glipizide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function with regular NSAID use. Use the lowest effective NSAID dose and shortest duration.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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