Drug interactions
Diclofenac + Glyburide-metformin
Severity: Moderate
Diclofenac and Glyburide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can enhance the glucose-lowering effect of sulfonylureas, with reports of hypoglycemia. NSAIDs may also impair renal function, which raises the risk of metformin accumulation and lactic acidosis.
What this interaction means in plain words
Diclofenac and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diclofenac belongs to Musculoskeletal; Glyburide-metformin belongs to Endocrine.
Why it happens
Possible displacement of glyburide from protein binding and altered prostaglandin-mediated insulin effects; NSAID-related renal impairment may reduce metformin clearance.
What to do
Monitor blood glucose and renal function during concurrent use, and use the lowest effective NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Frequently asked questions
Can I take Diclofenac with Glyburide-metformin?
MediHelp rates the interaction as moderate. Diclofenac and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can enhance the glucose-lowering effect of sulfonylureas, with reports of hypoglycemia. NSAIDs may also impair renal function, which raises the risk of metformin accumulation and lactic acidosis.
How serious is the interaction between Diclofenac and Glyburide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function during concurrent use, and use the lowest effective NSAID dose for the shortest time.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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