Drug interactions
Diclofenac + Hydralazine
Severity: Moderate
Diclofenac and Hydralazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diclofenac can blunt the blood pressure lowering effect of hydralazine. NSAID-related sodium and fluid retention may further reduce antihypertensive control.
What this interaction means in plain words
Diclofenac and Hydralazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diclofenac belongs to Musculoskeletal; Hydralazine belongs to Cardiovascular.
Why it happens
NSAIDs inhibit vasodilatory prostaglandin synthesis and promote sodium and water retention, opposing the vasodilator effect of hydralazine.
What to do
Monitor blood pressure when diclofenac is started, stopped or changed in a patient on hydralazine. Use the lowest effective NSAID dose for the shortest time and adjust antihypertensive therapy if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Benzphetamine + Hydralazine Moderate
Frequently asked questions
Can I take Diclofenac with Hydralazine?
MediHelp rates the interaction as moderate. Diclofenac and Hydralazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diclofenac can blunt the blood pressure lowering effect of hydralazine. NSAID-related sodium and fluid retention may further reduce antihypertensive control.
How serious is the interaction between Diclofenac and Hydralazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when diclofenac is started, stopped or changed in a patient on hydralazine. Use the lowest effective NSAID dose for the shortest time and adjust antihypertensive therapy if needed.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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