Drug interactions
Diclofenac + Hydrochlorothiazide-valsartan
Severity: Moderate
Diclofenac and Hydrochlorothiazide-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diclofenac can reduce the antihypertensive effect of valsartan and hydrochlorothiazide. In older or volume-depleted patients, the combination of an NSAID, diuretic and ARB can cause acute kidney injury and hyperkalemia.
What this interaction means in plain words
Diclofenac and Hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diclofenac belongs to Musculoskeletal; Hydrochlorothiazide-valsartan belongs to Cardiovascular.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces renal blood flow and sodium excretion, and combined with ARB and diuretic effects impairs glomerular filtration.
What to do
Monitor blood pressure, creatinine and potassium after starting diclofenac, and maintain hydration. Use the lowest effective dose for the shortest time or choose an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Frequently asked questions
Can I take Diclofenac with Hydrochlorothiazide-valsartan?
MediHelp rates the interaction as moderate. Diclofenac and Hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diclofenac can reduce the antihypertensive effect of valsartan and hydrochlorothiazide. In older or volume-depleted patients, the combination of an NSAID, diuretic and ARB can cause acute kidney injury and hyperkalemia.
How serious is the interaction between Diclofenac and Hydrochlorothiazide-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, creatinine and potassium after starting diclofenac, and maintain hydration. Use the lowest effective dose for the shortest time or choose an alternative analgesic.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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