Drug interactions
Diclofenac + Ivosidenib
Severity: Moderate
Diclofenac and Ivosidenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib can induce CYP enzymes and may lower exposure to CYP2C9 substrates such as diclofenac. This may reduce analgesic or anti-inflammatory effect, but the effect is usually modest.
What this interaction means in plain words
Diclofenac and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diclofenac belongs to Musculoskeletal; Ivosidenib belongs to Oncology.
Why it happens
Ivosidenib induction of CYP2C9 increases diclofenac metabolism.
What to do
Monitor for reduced diclofenac efficacy and adjust analgesia or choose an alternative if control is lost. Avoid escalating the NSAID dose beyond the usual maximum.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Diclofenac with Ivosidenib?
MediHelp rates the interaction as moderate. Diclofenac and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib can induce CYP enzymes and may lower exposure to CYP2C9 substrates such as diclofenac. This may reduce analgesic or anti-inflammatory effect, but the effect is usually modest.
How serious is the interaction between Diclofenac and Ivosidenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced diclofenac efficacy and adjust analgesia or choose an alternative if control is lost. Avoid escalating the NSAID dose beyond the usual maximum.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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