Drug interactions
Diclofenac + Meclofenamic acid
Severity: Major
Diclofenac and Meclofenamic acid: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two systemic NSAIDs increases gastrointestinal bleeding, renal injury and cardiovascular risk without added analgesic benefit. Meclofenamic acid and diclofenac should not be taken together routinely.
What this interaction means in plain words
Diclofenac and Meclofenamic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Diclofenac belongs to Musculoskeletal; Meclofenamic acid belongs to Musculoskeletal.
Why it happens
Additive cyclooxygenase inhibition affecting gastric, renal and platelet prostaglandin functions.
What to do
Avoid concurrent use and keep to one NSAID at the lowest effective dose. Add paracetamol or another non-NSAID option if more analgesia is required.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Frequently asked questions
Can I take Diclofenac with Meclofenamic acid?
MediHelp rates the interaction as major. Diclofenac and Meclofenamic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining two systemic NSAIDs increases gastrointestinal bleeding, renal injury and cardiovascular risk without added analgesic benefit. Meclofenamic acid and diclofenac should not be taken together routinely.
How serious is the interaction between Diclofenac and Meclofenamic acid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and keep to one NSAID at the lowest effective dose. Add paracetamol or another non-NSAID option if more analgesia is required.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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