Drug interactions
Diclofenac + Nateglinide
Severity: Minor
Diclofenac and Nateglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nateglinide is a weak CYP2C9 inhibitor in vitro and could slightly raise diclofenac exposure, but clinically meaningful change is unlikely. Diclofenac may also affect renal function in diabetic patients.
What this interaction means in plain words
Diclofenac and Nateglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Diclofenac belongs to Musculoskeletal; Nateglinide belongs to Endocrine.
Why it happens
Possible weak CYP2C9 inhibition by nateglinide reducing diclofenac metabolism.
What to do
No routine adjustment is required; monitor for NSAID adverse effects and renal function in diabetic patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Diclofenac with Nateglinide?
MediHelp rates the interaction as minor. Diclofenac and Nateglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nateglinide is a weak CYP2C9 inhibitor in vitro and could slightly raise diclofenac exposure, but clinically meaningful change is unlikely. Diclofenac may also affect renal function in diabetic patients.
How serious is the interaction between Diclofenac and Nateglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is required; monitor for NSAID adverse effects and renal function in diabetic patients.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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