Drug interactions
Diclofenac + Nilotinib
Severity: Moderate
Diclofenac and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib inhibits CYP2C9 in vitro and may increase diclofenac concentrations, enhancing NSAID adverse effects. NSAIDs may also add to bleeding or GI risk in oncology patients with thrombocytopenia.
What this interaction means in plain words
Diclofenac and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diclofenac belongs to Musculoskeletal; Nilotinib belongs to Oncology.
Why it happens
Inhibition of CYP2C9 by nilotinib reduces diclofenac metabolism.
What to do
Use the lowest effective diclofenac dose and monitor for GI bleeding, renal effects and platelet counts.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Diclofenac with Nilotinib?
MediHelp rates the interaction as moderate. Diclofenac and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib inhibits CYP2C9 in vitro and may increase diclofenac concentrations, enhancing NSAID adverse effects. NSAIDs may also add to bleeding or GI risk in oncology patients with thrombocytopenia.
How serious is the interaction between Diclofenac and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective diclofenac dose and monitor for GI bleeding, renal effects and platelet counts.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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