Drug interactions
Diclofenac + Streptomycin
Severity: Moderate
Diclofenac and Streptomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce renal function and prostaglandin-dependent renal perfusion, which may raise aminoglycoside concentrations. The concern is best documented in preterm infants given indomethacin or ibuprofen, and is less established for diclofenac in adults. Aminoglycoside nephrotoxicity and ototoxicity could be worsened.
What this interaction means in plain words
Diclofenac and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diclofenac belongs to Musculoskeletal; Streptomycin belongs to Anti Bacterial.
Why it happens
NSAID-induced reduction in renal blood flow and glomerular filtration may decrease aminoglycoside elimination.
What to do
Monitor serum creatinine and streptomycin concentrations where available, and avoid the combination in patients with renal impairment or dehydration. Keep NSAID courses short.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Streptomycin
Frequently asked questions
Can I take Diclofenac with Streptomycin?
MediHelp rates the interaction as moderate. Diclofenac and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce renal function and prostaglandin-dependent renal perfusion, which may raise aminoglycoside concentrations. The concern is best documented in preterm infants given indomethacin or ibuprofen, and is less established for diclofenac in adults. Aminoglycoside nephrotoxicity and ototoxicity could be worsened.
How serious is the interaction between Diclofenac and Streptomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and streptomycin concentrations where available, and avoid the combination in patients with renal impairment or dehydration. Keep NSAID courses short.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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