Drug interactions
Diclofenac + Tenecteplase
Severity: Major
Diclofenac and Tenecteplase: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diclofenac impairs platelet function and can injure the gastric mucosa, while tenecteplase causes fibrinolysis. The combination raises the risk of serious bleeding, including gastrointestinal and intracranial hemorrhage.
What this interaction means in plain words
Diclofenac and Tenecteplase can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Diclofenac belongs to Musculoskeletal; Tenecteplase belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effect of NSAID platelet inhibition and mucosal injury with thrombolytic fibrinolysis.
What to do
Avoid NSAIDs around thrombolytic therapy where possible, using paracetamol for pain. Monitor closely for bleeding if the combination is unavoidable.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Tenecteplase
- Alteplase + Tenecteplase Contraindicated
- Acetylsalicylic acid + Tenecteplase Major
- Apixaban + Tenecteplase Major
- Argatroban + Tenecteplase Major
- Dabigatran etexilate + Tenecteplase Major
- Dalteparin + Tenecteplase Major
Frequently asked questions
Can I take Diclofenac with Tenecteplase?
MediHelp rates the interaction as major. Diclofenac and Tenecteplase can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Diclofenac impairs platelet function and can injure the gastric mucosa, while tenecteplase causes fibrinolysis. The combination raises the risk of serious bleeding, including gastrointestinal and intracranial hemorrhage.
How serious is the interaction between Diclofenac and Tenecteplase?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid NSAIDs around thrombolytic therapy where possible, using paracetamol for pain. Monitor closely for bleeding if the combination is unavoidable.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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