Drug interactions
Diclofenac + Valganciclovir
Severity: Minor
Diclofenac and Valganciclovir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diclofenac and ganciclovir (the active form of valganciclovir) may compete for renal tubular secretion, potentially raising ganciclovir exposure. Both agents can affect the kidney, and valganciclovir toxicity includes myelosuppression. Clinical relevance is uncertain.
What this interaction means in plain words
Diclofenac and Valganciclovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Diclofenac belongs to Musculoskeletal; Valganciclovir belongs to Anti Virals.
Why it happens
Competition for renal tubular secretion via organic anion transporters may reduce ganciclovir clearance.
What to do
Monitor renal function and blood counts as already required for valganciclovir, and adjust the valganciclovir dose to creatinine clearance.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Valganciclovir
Frequently asked questions
Can I take Diclofenac with Valganciclovir?
MediHelp rates the interaction as minor. Diclofenac and Valganciclovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Diclofenac and ganciclovir (the active form of valganciclovir) may compete for renal tubular secretion, potentially raising ganciclovir exposure. Both agents can affect the kidney, and valganciclovir toxicity includes myelosuppression. Clinical relevance is uncertain.
How serious is the interaction between Diclofenac and Valganciclovir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and blood counts as already required for valganciclovir, and adjust the valganciclovir dose to creatinine clearance.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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