Drug interactions
Dicloxacillin + Dienogest / estradiol valerate
Severity: Minor
Dicloxacillin and Dienogest / estradiol valerate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dicloxacillin may modestly induce CYP3A4, which could lower hormone levels in a combined oral contraceptive. Evidence for loss of contraceptive efficacy with non-rifamycin antibiotics is weak.
What this interaction means in plain words
Dicloxacillin and Dienogest / estradiol valerate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak CYP3A4 induction increases metabolism of estradiol and dienogest.
What to do
Routine back-up contraception is generally not required, but advise it if vomiting or diarrhea occurs or if the patient prefers extra caution.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dicloxacillin
- Dicloxacillin + Phenindione Major
- Atogepant + Dicloxacillin Moderate
- Axitinib + Dicloxacillin Moderate
- Bcg vaccine live + Dicloxacillin Moderate
- Cholera vaccine + Dicloxacillin Moderate
- Demeclocycline + Dicloxacillin Moderate
Frequently asked questions
Can I take Dicloxacillin with Dienogest / estradiol valerate?
MediHelp rates the interaction as minor. Dicloxacillin and Dienogest / estradiol valerate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dicloxacillin may modestly induce CYP3A4, which could lower hormone levels in a combined oral contraceptive. Evidence for loss of contraceptive efficacy with non-rifamycin antibiotics is weak.
How serious is the interaction between Dicloxacillin and Dienogest / estradiol valerate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Routine back-up contraception is generally not required, but advise it if vomiting or diarrhea occurs or if the patient prefers extra caution.
What other medicines interact with Dicloxacillin?
MediHelp also lists interactions of Dicloxacillin with, for example, Phenindione, Atogepant, Axitinib. The full list is on the Dicloxacillin page.
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