Drug interactions
Dicloxacillin + Erythromycin stearate
Severity: Minor
Dicloxacillin and Erythromycin stearate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bacteriostatic macrolides have been proposed to blunt the activity of bactericidal beta-lactams, which need actively dividing bacteria. Clinical evidence of reduced outcomes is weak.
What this interaction means in plain words
Dicloxacillin and Erythromycin stearate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical pharmacodynamic antagonism: a bacteriostatic agent halts bacterial growth, reducing beta-lactam bactericidal activity.
What to do
No routine change is needed. Monitor clinical response in serious infections where bactericidal activity is essential.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dicloxacillin and Erythromycin stearate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dicloxacillin
- Dicloxacillin + Phenindione Major
- Atogepant + Dicloxacillin Moderate
- Axitinib + Dicloxacillin Moderate
- Bcg vaccine live + Dicloxacillin Moderate
- Cholera vaccine + Dicloxacillin Moderate
- Demeclocycline + Dicloxacillin Moderate
Frequently asked questions
Can I take Dicloxacillin with Erythromycin stearate?
MediHelp rates the interaction as minor. Dicloxacillin and Erythromycin stearate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bacteriostatic macrolides have been proposed to blunt the activity of bactericidal beta-lactams, which need actively dividing bacteria. Clinical evidence of reduced outcomes is weak.
How serious is the interaction between Dicloxacillin and Erythromycin stearate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Monitor clinical response in serious infections where bactericidal activity is essential.
What other medicines interact with Dicloxacillin?
MediHelp also lists interactions of Dicloxacillin with, for example, Phenindione, Atogepant, Axitinib. The full list is on the Dicloxacillin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
