Drug interactions
Dicloxacillin + Ethinyl estradiol-norgestimate
Severity: Minor
Dicloxacillin and Ethinyl estradiol-norgestimate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Non-enzyme-inducing antibiotics have been proposed to reduce contraceptive efficacy, but controlled data show no consistent fall in hormone levels or ovulation suppression. Any true risk is very low.
What this interaction means in plain words
Dicloxacillin and Ethinyl estradiol-norgestimate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dicloxacillin belongs to Anti Bacterial; Ethinyl estradiol-norgestimate belongs to Endocrine.
Why it happens
Proposed reduction of enterohepatic recirculation of estrogen through gut flora changes; not well established.
What to do
No additional contraception is routinely needed; counsel patients to take the pill consistently and use backup if vomiting or severe diarrhea occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-norgestimate
- Ethinyl estradiol-norgestimate + Fezolinetant Contraindicated
- Ethinyl estradiol-norgestimate + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-norgestimate + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-norgestimate Major
- Amobarbital + Ethinyl estradiol-norgestimate Major
- Anastrozole + Ethinyl estradiol-norgestimate Major
Other interactions of Dicloxacillin
- Dicloxacillin + Phenindione Major
- Atogepant + Dicloxacillin Moderate
- Axitinib + Dicloxacillin Moderate
- Bcg vaccine live + Dicloxacillin Moderate
- Cholera vaccine + Dicloxacillin Moderate
- Demeclocycline + Dicloxacillin Moderate
Frequently asked questions
Can I take Dicloxacillin with Ethinyl estradiol-norgestimate?
MediHelp rates the interaction as minor. Dicloxacillin and Ethinyl estradiol-norgestimate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Non-enzyme-inducing antibiotics have been proposed to reduce contraceptive efficacy, but controlled data show no consistent fall in hormone levels or ovulation suppression. Any true risk is very low.
How serious is the interaction between Dicloxacillin and Ethinyl estradiol-norgestimate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No additional contraception is routinely needed; counsel patients to take the pill consistently and use backup if vomiting or severe diarrhea occurs.
What other medicines interact with Ethinyl estradiol-norgestimate?
MediHelp also lists interactions of Ethinyl estradiol-norgestimate with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-norgestimate page.
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