Drug interactions
Dicloxacillin + Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate
Severity: Minor
Dicloxacillin and Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Penicillin-class antibiotics have been theorized to reduce the efficacy of combined oral contraceptives, but pharmacokinetic and clinical data do not show a meaningful loss of contraceptive protection. The risk is regarded as very low.
What this interaction means in plain words
Dicloxacillin and Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical disruption of gut flora and enterohepatic recycling of ethinylestradiol; not demonstrated for penicillins.
What to do
No additional contraception is routinely required; reinforce adherence and advise backup methods if vomiting or severe diarrhea occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dicloxacillin
- Dicloxacillin + Phenindione Major
- Atogepant + Dicloxacillin Moderate
- Axitinib + Dicloxacillin Moderate
- Bcg vaccine live + Dicloxacillin Moderate
- Cholera vaccine + Dicloxacillin Moderate
- Demeclocycline + Dicloxacillin Moderate
Frequently asked questions
Can I take Dicloxacillin with Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate?
MediHelp rates the interaction as minor. Dicloxacillin and Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Penicillin-class antibiotics have been theorized to reduce the efficacy of combined oral contraceptives, but pharmacokinetic and clinical data do not show a meaningful loss of contraceptive protection. The risk is regarded as very low.
How serious is the interaction between Dicloxacillin and Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No additional contraception is routinely required; reinforce adherence and advise backup methods if vomiting or severe diarrhea occurs.
What other medicines interact with Dicloxacillin?
MediHelp also lists interactions of Dicloxacillin with, for example, Phenindione, Atogepant, Axitinib. The full list is on the Dicloxacillin page.
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