Drug interactions
Dicloxacillin + Mestranol
Severity: Minor
Dicloxacillin and Mestranol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antibiotics are theorized to lower the effectiveness of estrogen-containing oral contraceptives such as mestranol, though evidence for penicillins shows little or no effect. Contraceptive failure is unlikely.
What this interaction means in plain words
Dicloxacillin and Mestranol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical reduction of intestinal flora that recycle estrogen via enterohepatic circulation; not established for penicillins.
What to do
No routine change is needed; advise continued pill use and backup contraception only if vomiting or severe diarrhea occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dicloxacillin
- Dicloxacillin + Phenindione Major
- Atogepant + Dicloxacillin Moderate
- Axitinib + Dicloxacillin Moderate
- Bcg vaccine live + Dicloxacillin Moderate
- Cholera vaccine + Dicloxacillin Moderate
- Demeclocycline + Dicloxacillin Moderate
Frequently asked questions
Can I take Dicloxacillin with Mestranol?
MediHelp rates the interaction as minor. Dicloxacillin and Mestranol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antibiotics are theorized to lower the effectiveness of estrogen-containing oral contraceptives such as mestranol, though evidence for penicillins shows little or no effect. Contraceptive failure is unlikely.
How serious is the interaction between Dicloxacillin and Mestranol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; advise continued pill use and backup contraception only if vomiting or severe diarrhea occurs.
What other medicines interact with Dicloxacillin?
MediHelp also lists interactions of Dicloxacillin with, for example, Phenindione, Atogepant, Axitinib. The full list is on the Dicloxacillin page.
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