Drug interactions
Dicloxacillin + Microbiota
Severity: Moderate
Dicloxacillin and Microbiota: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral microbiota products contain live bacterial spores meant to recolonize the gut. Concurrent dicloxacillin may act against them, lowering engraftment and effectiveness.
What this interaction means in plain words
Dicloxacillin and Microbiota can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibacterial activity of dicloxacillin against the live microbiota components reduces colonization (pharmacodynamic antagonism).
What to do
Complete the antibiotic course and wait at least 2 to 4 days before starting oral microbiota, per labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dicloxacillin
- Dicloxacillin + Phenindione Major
- Atogepant + Dicloxacillin Moderate
- Axitinib + Dicloxacillin Moderate
- Bcg vaccine live + Dicloxacillin Moderate
- Cholera vaccine + Dicloxacillin Moderate
- Demeclocycline + Dicloxacillin Moderate
Frequently asked questions
Can I take Dicloxacillin with Microbiota?
MediHelp rates the interaction as moderate. Dicloxacillin and Microbiota can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral microbiota products contain live bacterial spores meant to recolonize the gut. Concurrent dicloxacillin may act against them, lowering engraftment and effectiveness.
How serious is the interaction between Dicloxacillin and Microbiota?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Complete the antibiotic course and wait at least 2 to 4 days before starting oral microbiota, per labeling.
What other medicines interact with Dicloxacillin?
MediHelp also lists interactions of Dicloxacillin with, for example, Phenindione, Atogepant, Axitinib. The full list is on the Dicloxacillin page.
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