Drug interactions
Dicloxacillin + Mycophenolate
Severity: Moderate
Dicloxacillin and Mycophenolate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Some antibiotics reduce exposure to mycophenolic acid, the active metabolite of mycophenolate, which may weaken immunosuppression. Evidence for penicillins specifically is limited, but graft rejection risk makes the concern relevant in transplant patients.
What this interaction means in plain words
Dicloxacillin and Mycophenolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibiotic-related alteration of gut flora may reduce deconjugation of mycophenolic acid glucuronide and thus enterohepatic recirculation.
What to do
Monitor for signs of reduced immunosuppression and consider mycophenolic acid exposure monitoring in transplant recipients during and after the antibiotic course.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dicloxacillin
- Dicloxacillin + Phenindione Major
- Atogepant + Dicloxacillin Moderate
- Axitinib + Dicloxacillin Moderate
- Bcg vaccine live + Dicloxacillin Moderate
- Cholera vaccine + Dicloxacillin Moderate
- Demeclocycline + Dicloxacillin Moderate
Frequently asked questions
Can I take Dicloxacillin with Mycophenolate?
MediHelp rates the interaction as moderate. Dicloxacillin and Mycophenolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Some antibiotics reduce exposure to mycophenolic acid, the active metabolite of mycophenolate, which may weaken immunosuppression. Evidence for penicillins specifically is limited, but graft rejection risk makes the concern relevant in transplant patients.
How serious is the interaction between Dicloxacillin and Mycophenolate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of reduced immunosuppression and consider mycophenolic acid exposure monitoring in transplant recipients during and after the antibiotic course.
What other medicines interact with Dicloxacillin?
MediHelp also lists interactions of Dicloxacillin with, for example, Phenindione, Atogepant, Axitinib. The full list is on the Dicloxacillin page.
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