Drug interactions
Dicloxacillin + Parecoxib
Severity: Minor
Dicloxacillin and Parecoxib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Parecoxib's active metabolite valdecoxib and dicloxacillin are both highly protein bound and renally cleared, but no clinically significant interaction has been documented.
What this interaction means in plain words
Dicloxacillin and Parecoxib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical protein binding displacement and competition for renal secretion.
What to do
No dose adjustment is needed; monitor renal function if the patient has other risk factors for kidney injury.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dicloxacillin
- Dicloxacillin + Phenindione Major
- Atogepant + Dicloxacillin Moderate
- Axitinib + Dicloxacillin Moderate
- Bcg vaccine live + Dicloxacillin Moderate
- Cholera vaccine + Dicloxacillin Moderate
- Demeclocycline + Dicloxacillin Moderate
Frequently asked questions
Can I take Dicloxacillin with Parecoxib?
MediHelp rates the interaction as minor. Dicloxacillin and Parecoxib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Parecoxib's active metabolite valdecoxib and dicloxacillin are both highly protein bound and renally cleared, but no clinically significant interaction has been documented.
How serious is the interaction between Dicloxacillin and Parecoxib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor renal function if the patient has other risk factors for kidney injury.
What other medicines interact with Dicloxacillin?
MediHelp also lists interactions of Dicloxacillin with, for example, Phenindione, Atogepant, Axitinib. The full list is on the Dicloxacillin page.
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