Drug interactions
Dicloxacillin + Salsalate
Severity: Minor
Dicloxacillin and Salsalate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate is hydrolyzed to salicylic acid, which may compete with dicloxacillin for protein binding and tubular secretion. The resulting increase in penicillin exposure is likely small.
What this interaction means in plain words
Dicloxacillin and Salsalate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for renal tubular secretion and plasma protein binding by salicylate.
What to do
No dose change is typically required; monitor for adverse effects if both are used at high doses or in renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dicloxacillin
- Dicloxacillin + Phenindione Major
- Atogepant + Dicloxacillin Moderate
- Axitinib + Dicloxacillin Moderate
- Bcg vaccine live + Dicloxacillin Moderate
- Cholera vaccine + Dicloxacillin Moderate
- Demeclocycline + Dicloxacillin Moderate
Frequently asked questions
Can I take Dicloxacillin with Salsalate?
MediHelp rates the interaction as minor. Dicloxacillin and Salsalate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Salsalate is hydrolyzed to salicylic acid, which may compete with dicloxacillin for protein binding and tubular secretion. The resulting increase in penicillin exposure is likely small.
How serious is the interaction between Dicloxacillin and Salsalate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is typically required; monitor for adverse effects if both are used at high doses or in renal impairment.
What other medicines interact with Dicloxacillin?
MediHelp also lists interactions of Dicloxacillin with, for example, Phenindione, Atogepant, Axitinib. The full list is on the Dicloxacillin page.
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