Drug interactions
Dicyclomine + Glycopyrrolate inhaled
Severity: Moderate
Dicyclomine and Glycopyrrolate inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inhaled glycopyrrolate is partly absorbed systemically, so it can add to the anticholinergic burden of oral dicyclomine. This may worsen dry mouth, constipation, urinary retention and blurred vision, especially in older patients.
What this interaction means in plain words
Dicyclomine and Glycopyrrolate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive muscarinic receptor blockade, with systemic exposure from the inhaled dose.
What to do
Monitor for urinary retention, constipation and worsening narrow-angle glaucoma symptoms; consider a lower dicyclomine dose if anticholinergic effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dicyclomine
- Clozapine + Dicyclomine Major
- Dicyclomine + Henbane Major
- Dicyclomine + Imipramine Major
- Dicyclomine + Pramlintide Major
- Abobotulinumtoxina + Dicyclomine Moderate
- Aclidinium + Dicyclomine Moderate
Frequently asked questions
Can I take Dicyclomine with Glycopyrrolate inhaled?
MediHelp rates the interaction as moderate. Dicyclomine and Glycopyrrolate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Inhaled glycopyrrolate is partly absorbed systemically, so it can add to the anticholinergic burden of oral dicyclomine. This may worsen dry mouth, constipation, urinary retention and blurred vision, especially in older patients.
How serious is the interaction between Dicyclomine and Glycopyrrolate inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for urinary retention, constipation and worsening narrow-angle glaucoma symptoms; consider a lower dicyclomine dose if anticholinergic effects occur.
What other medicines interact with Dicyclomine?
MediHelp also lists interactions of Dicyclomine with, for example, Clozapine, Henbane, Imipramine. The full list is on the Dicyclomine page.
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