Drug interactions
Dicyclomine + Glycopyrronium tosylate
Severity: Moderate
Dicyclomine and Glycopyrronium tosylate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Topical glycopyrronium has some systemic absorption and may add to the anticholinergic effects of dicyclomine. This can cause dry mouth, blurred vision, urinary retention and constipation.
What this interaction means in plain words
Dicyclomine and Glycopyrronium tosylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects at peripheral cholinergic receptors.
What to do
Monitor for anticholinergic effects such as urinary retention, blurred vision and constipation. Reduce the dicyclomine dose or stop one agent if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dicyclomine
- Clozapine + Dicyclomine Major
- Dicyclomine + Henbane Major
- Dicyclomine + Imipramine Major
- Dicyclomine + Pramlintide Major
- Abobotulinumtoxina + Dicyclomine Moderate
- Aclidinium + Dicyclomine Moderate
Frequently asked questions
Can I take Dicyclomine with Glycopyrronium tosylate?
MediHelp rates the interaction as moderate. Dicyclomine and Glycopyrronium tosylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Topical glycopyrronium has some systemic absorption and may add to the anticholinergic effects of dicyclomine. This can cause dry mouth, blurred vision, urinary retention and constipation.
How serious is the interaction between Dicyclomine and Glycopyrronium tosylate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects such as urinary retention, blurred vision and constipation. Reduce the dicyclomine dose or stop one agent if symptoms develop.
What other medicines interact with Dicyclomine?
MediHelp also lists interactions of Dicyclomine with, for example, Clozapine, Henbane, Imipramine. The full list is on the Dicyclomine page.
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