Drug interactions
Dicyclomine + Hyoscyamine spray
Severity: Moderate
Dicyclomine and Hyoscyamine spray: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hyoscyamine given as an oral or sublingual spray is absorbed systemically and adds to the anticholinergic effects of dicyclomine. This raises the risk of dry mouth, constipation, urinary retention, blurred vision and confusion.
What this interaction means in plain words
Dicyclomine and Hyoscyamine spray can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Avoid duplicate antimuscarinic therapy; if both are required, monitor for anticholinergic toxicity and reduce doses as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dicyclomine
- Clozapine + Dicyclomine Major
- Dicyclomine + Henbane Major
- Dicyclomine + Imipramine Major
- Dicyclomine + Pramlintide Major
- Abobotulinumtoxina + Dicyclomine Moderate
- Aclidinium + Dicyclomine Moderate
Frequently asked questions
Can I take Dicyclomine with Hyoscyamine spray?
MediHelp rates the interaction as moderate. Dicyclomine and Hyoscyamine spray can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hyoscyamine given as an oral or sublingual spray is absorbed systemically and adds to the anticholinergic effects of dicyclomine. This raises the risk of dry mouth, constipation, urinary retention, blurred vision and confusion.
How serious is the interaction between Dicyclomine and Hyoscyamine spray?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicate antimuscarinic therapy; if both are required, monitor for anticholinergic toxicity and reduce doses as needed.
What other medicines interact with Dicyclomine?
MediHelp also lists interactions of Dicyclomine with, for example, Clozapine, Henbane, Imipramine. The full list is on the Dicyclomine page.
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