Drug interactions
Dicyclomine + Meclizine
Severity: Moderate
Dicyclomine and Meclizine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meclizine is an antihistamine with anticholinergic activity, so combined use adds to sedation and antimuscarinic effects. Dry mouth, constipation, urinary retention, drowsiness and confusion may become troublesome.
What this interaction means in plain words
Dicyclomine and Meclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dicyclomine belongs to Respiratory; Meclizine belongs to Respiratory.
Why it happens
Additive antimuscarinic effects, with added central sedation from H1 blockade.
What to do
Monitor for sedation, confusion and urinary or bowel symptoms, especially in older patients. Use the lowest effective doses or choose a non-anticholinergic alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dicyclomine
- Clozapine + Dicyclomine Major
- Dicyclomine + Henbane Major
- Dicyclomine + Imipramine Major
- Dicyclomine + Pramlintide Major
- Abobotulinumtoxina + Dicyclomine Moderate
- Aclidinium + Dicyclomine Moderate
Other interactions of Meclizine
Frequently asked questions
Can I take Dicyclomine with Meclizine?
MediHelp rates the interaction as moderate. Dicyclomine and Meclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meclizine is an antihistamine with anticholinergic activity, so combined use adds to sedation and antimuscarinic effects. Dry mouth, constipation, urinary retention, drowsiness and confusion may become troublesome.
How serious is the interaction between Dicyclomine and Meclizine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, confusion and urinary or bowel symptoms, especially in older patients. Use the lowest effective doses or choose a non-anticholinergic alternative.
What other medicines interact with Dicyclomine?
MediHelp also lists interactions of Dicyclomine with, for example, Clozapine, Henbane, Imipramine. The full list is on the Dicyclomine page.
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