Drug interactions
Dicyclomine + Metoclopramide intranasal
Severity: Moderate
Dicyclomine and Metoclopramide intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide promotes gastric motility through cholinergic and dopaminergic mechanisms, while dicyclomine slows motility. They therefore oppose each other, and the prokinetic effect of metoclopramide may be reduced.
What this interaction means in plain words
Dicyclomine and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism: antimuscarinic blockade counters the prokinetic action of metoclopramide.
What to do
Monitor for reduced symptom control of gastroparesis or nausea; avoid the combination if the prokinetic effect is the treatment goal.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dicyclomine
- Clozapine + Dicyclomine Major
- Dicyclomine + Henbane Major
- Dicyclomine + Imipramine Major
- Dicyclomine + Pramlintide Major
- Abobotulinumtoxina + Dicyclomine Moderate
- Aclidinium + Dicyclomine Moderate
Frequently asked questions
Can I take Dicyclomine with Metoclopramide intranasal?
MediHelp rates the interaction as moderate. Dicyclomine and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide promotes gastric motility through cholinergic and dopaminergic mechanisms, while dicyclomine slows motility. They therefore oppose each other, and the prokinetic effect of metoclopramide may be reduced.
How serious is the interaction between Dicyclomine and Metoclopramide intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced symptom control of gastroparesis or nausea; avoid the combination if the prokinetic effect is the treatment goal.
What other medicines interact with Dicyclomine?
MediHelp also lists interactions of Dicyclomine with, for example, Clozapine, Henbane, Imipramine. The full list is on the Dicyclomine page.
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