Drug interactions
Dicyclomine + Olanzapine
Severity: Moderate
Dicyclomine and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine has clinically meaningful anticholinergic activity, so adding dicyclomine increases the risk of constipation, ileus, urinary retention, dry mouth, tachycardia and confusion. Slowed GI motility may also affect absorption of oral drugs.
What this interaction means in plain words
Dicyclomine and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dicyclomine belongs to Respiratory; Olanzapine belongs to Central Nervous System.
Why it happens
Additive antimuscarinic effects.
What to do
Monitor bowel function, urinary symptoms and mental status. Avoid or minimize dicyclomine in older or constipated patients taking olanzapine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dicyclomine
- Clozapine + Dicyclomine Major
- Dicyclomine + Henbane Major
- Dicyclomine + Imipramine Major
- Dicyclomine + Pramlintide Major
- Abobotulinumtoxina + Dicyclomine Moderate
- Aclidinium + Dicyclomine Moderate
Other interactions of Olanzapine
Frequently asked questions
Can I take Dicyclomine with Olanzapine?
MediHelp rates the interaction as moderate. Dicyclomine and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine has clinically meaningful anticholinergic activity, so adding dicyclomine increases the risk of constipation, ileus, urinary retention, dry mouth, tachycardia and confusion. Slowed GI motility may also affect absorption of oral drugs.
How serious is the interaction between Dicyclomine and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor bowel function, urinary symptoms and mental status. Avoid or minimize dicyclomine in older or constipated patients taking olanzapine.
What other medicines interact with Dicyclomine?
MediHelp also lists interactions of Dicyclomine with, for example, Clozapine, Henbane, Imipramine. The full list is on the Dicyclomine page.
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