Drug interactions
Dicyclomine + Orphenadrine
Severity: Moderate
Dicyclomine and Orphenadrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Orphenadrine is a muscle relaxant with strong anticholinergic properties, so with dicyclomine it produces additive anticholinergic effects. Confusion, tachycardia, dry mouth, constipation and urinary retention are more likely, particularly in older people.
What this interaction means in plain words
Dicyclomine and Orphenadrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Avoid the combination in older adults; otherwise monitor for CNS and peripheral anticholinergic effects and reduce doses if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dicyclomine
- Clozapine + Dicyclomine Major
- Dicyclomine + Henbane Major
- Dicyclomine + Imipramine Major
- Dicyclomine + Pramlintide Major
- Abobotulinumtoxina + Dicyclomine Moderate
- Aclidinium + Dicyclomine Moderate
Frequently asked questions
Can I take Dicyclomine with Orphenadrine?
MediHelp rates the interaction as moderate. Dicyclomine and Orphenadrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Orphenadrine is a muscle relaxant with strong anticholinergic properties, so with dicyclomine it produces additive anticholinergic effects. Confusion, tachycardia, dry mouth, constipation and urinary retention are more likely, particularly in older people.
How serious is the interaction between Dicyclomine and Orphenadrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in older adults; otherwise monitor for CNS and peripheral anticholinergic effects and reduce doses if they occur.
What other medicines interact with Dicyclomine?
MediHelp also lists interactions of Dicyclomine with, for example, Clozapine, Henbane, Imipramine. The full list is on the Dicyclomine page.
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