Drug interactions
Dicyclomine + Physostigmine
Severity: Moderate
Dicyclomine and Physostigmine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Physostigmine inhibits acetylcholinesterase and is used to reverse anticholinergic toxicity, so it opposes the effect of dicyclomine. Dicyclomine can blunt physostigmine's cholinergic effects, and physostigmine can overcome dicyclomine's antispasmodic action.
What this interaction means in plain words
Dicyclomine and Physostigmine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism between cholinesterase inhibition and muscarinic receptor blockade.
What to do
Avoid routine co-use; when physostigmine is used to treat anticholinergic toxicity, monitor for bradycardia, seizures and cholinergic effects with resuscitation equipment available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dicyclomine
- Clozapine + Dicyclomine Major
- Dicyclomine + Henbane Major
- Dicyclomine + Imipramine Major
- Dicyclomine + Pramlintide Major
- Abobotulinumtoxina + Dicyclomine Moderate
- Aclidinium + Dicyclomine Moderate
Frequently asked questions
Can I take Dicyclomine with Physostigmine?
MediHelp rates the interaction as moderate. Dicyclomine and Physostigmine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Physostigmine inhibits acetylcholinesterase and is used to reverse anticholinergic toxicity, so it opposes the effect of dicyclomine. Dicyclomine can blunt physostigmine's cholinergic effects, and physostigmine can overcome dicyclomine's antispasmodic action.
How serious is the interaction between Dicyclomine and Physostigmine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine co-use; when physostigmine is used to treat anticholinergic toxicity, monitor for bradycardia, seizures and cholinergic effects with resuscitation equipment available.
What other medicines interact with Dicyclomine?
MediHelp also lists interactions of Dicyclomine with, for example, Clozapine, Henbane, Imipramine. The full list is on the Dicyclomine page.
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