Drug interactions
Dicyclomine + Pimozide
Severity: Moderate
Dicyclomine and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pimozide has some anticholinergic activity, so combining it with dicyclomine adds to constipation, dry mouth, urinary retention and confusion. Pimozide's QT prolongation is not affected by dicyclomine, but tachycardia from anticholinergics is undesirable in these patients.
What this interaction means in plain words
Dicyclomine and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dicyclomine belongs to Respiratory; Pimozide belongs to Central Nervous System.
Why it happens
Additive antimuscarinic effects; possible altered absorption from slowed GI motility.
What to do
Monitor for anticholinergic effects and heart rate, and use the lowest effective dicyclomine dose. Ensure ECG monitoring appropriate for pimozide continues.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dicyclomine and Pimozide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dicyclomine
- Clozapine + Dicyclomine Major
- Dicyclomine + Henbane Major
- Dicyclomine + Imipramine Major
- Dicyclomine + Pramlintide Major
- Abobotulinumtoxina + Dicyclomine Moderate
- Aclidinium + Dicyclomine Moderate
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Dicyclomine with Pimozide?
MediHelp rates the interaction as moderate. Dicyclomine and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pimozide has some anticholinergic activity, so combining it with dicyclomine adds to constipation, dry mouth, urinary retention and confusion. Pimozide's QT prolongation is not affected by dicyclomine, but tachycardia from anticholinergics is undesirable in these patients.
How serious is the interaction between Dicyclomine and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects and heart rate, and use the lowest effective dicyclomine dose. Ensure ECG monitoring appropriate for pimozide continues.
What other medicines interact with Dicyclomine?
MediHelp also lists interactions of Dicyclomine with, for example, Clozapine, Henbane, Imipramine. The full list is on the Dicyclomine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
