Drug interactions
Dicyclomine + Protriptyline
Severity: Moderate
Dicyclomine and Protriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Protriptyline is a tricyclic antidepressant with notable antimuscarinic activity, so together with dicyclomine it increases anticholinergic burden. Tachycardia, urinary retention, constipation, dry mouth and confusion are more likely, especially in older patients.
What this interaction means in plain words
Dicyclomine and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Monitor heart rate, bowel and bladder function and mental status; reduce the dicyclomine dose or choose a less anticholinergic antidepressant if effects arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dicyclomine
- Clozapine + Dicyclomine Major
- Dicyclomine + Henbane Major
- Dicyclomine + Imipramine Major
- Dicyclomine + Pramlintide Major
- Abobotulinumtoxina + Dicyclomine Moderate
- Aclidinium + Dicyclomine Moderate
Frequently asked questions
Can I take Dicyclomine with Protriptyline?
MediHelp rates the interaction as moderate. Dicyclomine and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Protriptyline is a tricyclic antidepressant with notable antimuscarinic activity, so together with dicyclomine it increases anticholinergic burden. Tachycardia, urinary retention, constipation, dry mouth and confusion are more likely, especially in older patients.
How serious is the interaction between Dicyclomine and Protriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, bowel and bladder function and mental status; reduce the dicyclomine dose or choose a less anticholinergic antidepressant if effects arise.
What other medicines interact with Dicyclomine?
MediHelp also lists interactions of Dicyclomine with, for example, Clozapine, Henbane, Imipramine. The full list is on the Dicyclomine page.
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