Drug interactions
Dicyclomine + Thiothixene
Severity: Moderate
Dicyclomine and Thiothixene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have anticholinergic activity, so using them together can add to dry mouth, constipation, urinary retention, blurred vision and confusion. Reduced gut motility from dicyclomine could in theory alter oral thiothixene absorption, but this is poorly documented.
What this interaction means in plain words
Dicyclomine and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive anticholinergic effects, with possible delayed GI absorption of thiothixene from slowed motility.
What to do
Monitor for anticholinergic toxicity, especially in older adults, and for loss of antipsychotic effect. Lower the anticholinergic burden if symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dicyclomine
- Clozapine + Dicyclomine Major
- Dicyclomine + Henbane Major
- Dicyclomine + Imipramine Major
- Dicyclomine + Pramlintide Major
- Abobotulinumtoxina + Dicyclomine Moderate
- Aclidinium + Dicyclomine Moderate
Frequently asked questions
Can I take Dicyclomine with Thiothixene?
MediHelp rates the interaction as moderate. Dicyclomine and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have anticholinergic activity, so using them together can add to dry mouth, constipation, urinary retention, blurred vision and confusion. Reduced gut motility from dicyclomine could in theory alter oral thiothixene absorption, but this is poorly documented.
How serious is the interaction between Dicyclomine and Thiothixene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity, especially in older adults, and for loss of antipsychotic effect. Lower the anticholinergic burden if symptoms appear.
What other medicines interact with Dicyclomine?
MediHelp also lists interactions of Dicyclomine with, for example, Clozapine, Henbane, Imipramine. The full list is on the Dicyclomine page.
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