Drug interactions
Dicyclomine + Trihexyphenidyl
Severity: Moderate
Dicyclomine and Trihexyphenidyl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are potent anticholinergics, and combining them raises the risk of dry mouth, constipation, urinary retention, tachycardia, confusion, hallucinations and heat intolerance. Older patients are especially prone to delirium and paralytic ileus.
What this interaction means in plain words
Dicyclomine and Trihexyphenidyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dicyclomine belongs to Respiratory; Trihexyphenidyl belongs to Central Nervous System.
Why it happens
Additive antimuscarinic pharmacodynamic effects.
What to do
Monitor for anticholinergic toxicity including cognitive change, ileus and urinary retention, and lower the dose or stop one agent if it occurs. Avoid in elderly or cognitively impaired patients when alternatives exist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dicyclomine
- Clozapine + Dicyclomine Major
- Dicyclomine + Henbane Major
- Dicyclomine + Imipramine Major
- Dicyclomine + Pramlintide Major
- Abobotulinumtoxina + Dicyclomine Moderate
- Aclidinium + Dicyclomine Moderate
Other interactions of Trihexyphenidyl
Frequently asked questions
Can I take Dicyclomine with Trihexyphenidyl?
MediHelp rates the interaction as moderate. Dicyclomine and Trihexyphenidyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are potent anticholinergics, and combining them raises the risk of dry mouth, constipation, urinary retention, tachycardia, confusion, hallucinations and heat intolerance. Older patients are especially prone to delirium and paralytic ileus.
How serious is the interaction between Dicyclomine and Trihexyphenidyl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity including cognitive change, ileus and urinary retention, and lower the dose or stop one agent if it occurs. Avoid in elderly or cognitively impaired patients when alternatives exist.
What other medicines interact with Dicyclomine?
MediHelp also lists interactions of Dicyclomine with, for example, Clozapine, Henbane, Imipramine. The full list is on the Dicyclomine page.
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