Drug interactions
Dicyclomine + Umeclidinium bromide / vilanterol inhaled
Severity: Moderate
Dicyclomine and Umeclidinium bromide / vilanterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Umeclidinium is an inhaled antimuscarinic with low systemic exposure, and it may add to the anticholinergic effects of oral dicyclomine. This can cause dry mouth, urinary retention, constipation and blurred vision.
What this interaction means in plain words
Dicyclomine and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects at peripheral cholinergic receptors.
What to do
Monitor for urinary retention, constipation, and worsening glaucoma symptoms. Reduce or stop dicyclomine if anticholinergic effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dicyclomine and Umeclidinium bromide / vilanterol inhaled, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dicyclomine
- Clozapine + Dicyclomine Major
- Dicyclomine + Henbane Major
- Dicyclomine + Imipramine Major
- Dicyclomine + Pramlintide Major
- Abobotulinumtoxina + Dicyclomine Moderate
- Aclidinium + Dicyclomine Moderate
Frequently asked questions
Can I take Dicyclomine with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as moderate. Dicyclomine and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Umeclidinium is an inhaled antimuscarinic with low systemic exposure, and it may add to the anticholinergic effects of oral dicyclomine. This can cause dry mouth, urinary retention, constipation and blurred vision.
How serious is the interaction between Dicyclomine and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for urinary retention, constipation, and worsening glaucoma symptoms. Reduce or stop dicyclomine if anticholinergic effects develop.
What other medicines interact with Dicyclomine?
MediHelp also lists interactions of Dicyclomine with, for example, Clozapine, Henbane, Imipramine. The full list is on the Dicyclomine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
