Drug interactions
Dicyclomine + Umeclidinium bromide
Severity: Moderate
Dicyclomine and Umeclidinium bromide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Umeclidinium is an inhaled antimuscarinic with low systemic exposure, but combining it with oral dicyclomine adds to the total anticholinergic burden. This may worsen dry mouth, constipation, urinary retention, tachycardia and glaucoma symptoms.
What this interaction means in plain words
Dicyclomine and Umeclidinium bromide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Avoid additional anticholinergics where possible. Monitor for urinary retention, constipation and ocular symptoms, particularly in patients with prostatic enlargement or narrow-angle glaucoma.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dicyclomine
- Clozapine + Dicyclomine Major
- Dicyclomine + Henbane Major
- Dicyclomine + Imipramine Major
- Dicyclomine + Pramlintide Major
- Abobotulinumtoxina + Dicyclomine Moderate
- Aclidinium + Dicyclomine Moderate
Frequently asked questions
Can I take Dicyclomine with Umeclidinium bromide?
MediHelp rates the interaction as moderate. Dicyclomine and Umeclidinium bromide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Umeclidinium is an inhaled antimuscarinic with low systemic exposure, but combining it with oral dicyclomine adds to the total anticholinergic burden. This may worsen dry mouth, constipation, urinary retention, tachycardia and glaucoma symptoms.
How serious is the interaction between Dicyclomine and Umeclidinium bromide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid additional anticholinergics where possible. Monitor for urinary retention, constipation and ocular symptoms, particularly in patients with prostatic enlargement or narrow-angle glaucoma.
What other medicines interact with Dicyclomine?
MediHelp also lists interactions of Dicyclomine with, for example, Clozapine, Henbane, Imipramine. The full list is on the Dicyclomine page.
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