Drug interactions
Dicyclomine + Zotepine
Severity: Moderate
Dicyclomine and Zotepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zotepine has anticholinergic properties, so adding dicyclomine can increase peripheral and central anticholinergic effects such as constipation, urinary retention, dry mouth and confusion. Slowed GI motility might theoretically alter zotepine absorption, but this is not well established.
What this interaction means in plain words
Dicyclomine and Zotepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive anticholinergic effects, with possible altered GI absorption from reduced motility.
What to do
Monitor for anticholinergic toxicity and for changes in antipsychotic response. Avoid combining where other options exist, especially in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dicyclomine
- Clozapine + Dicyclomine Major
- Dicyclomine + Henbane Major
- Dicyclomine + Imipramine Major
- Dicyclomine + Pramlintide Major
- Abobotulinumtoxina + Dicyclomine Moderate
- Aclidinium + Dicyclomine Moderate
Frequently asked questions
Can I take Dicyclomine with Zotepine?
MediHelp rates the interaction as moderate. Dicyclomine and Zotepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zotepine has anticholinergic properties, so adding dicyclomine can increase peripheral and central anticholinergic effects such as constipation, urinary retention, dry mouth and confusion. Slowed GI motility might theoretically alter zotepine absorption, but this is not well established.
How serious is the interaction between Dicyclomine and Zotepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and for changes in antipsychotic response. Avoid combining where other options exist, especially in older patients.
What other medicines interact with Dicyclomine?
MediHelp also lists interactions of Dicyclomine with, for example, Clozapine, Henbane, Imipramine. The full list is on the Dicyclomine page.
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