Drug interactions
Didanosine + Doxycycline
Severity: Moderate
Didanosine and Doxycycline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buffered didanosine formulations contain magnesium and aluminium antacids that bind doxycycline in the gut. Absorption of doxycycline falls, which may compromise treatment.
What this interaction means in plain words
Didanosine and Doxycycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Didanosine belongs to Anti Virals; Doxycycline belongs to Anti Bacterial.
Why it happens
Chelation of doxycycline by polyvalent cations in buffered didanosine, reducing gastrointestinal absorption.
What to do
Give doxycycline at least 2 hours before buffered didanosine, or use a non-chelating alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxycycline
- Acitretin + Doxycycline Contraindicated
- Aminolevulinic acid + Doxycycline Major
- Cholera vaccine + Doxycycline Major
- Doxycycline + Isotretinoin Major
- Doxycycline + Methoxyflurane Major
- Doxycycline + Microbiota Major
Other interactions of Didanosine
- Didanosine + Elvitegravir / cobicistat / emtricitabine / tenofovir df Contraindicated
- Didanosine + Hydroxycarbamide Contraindicated
- Didanosine + Ribavirin Contraindicated
- Didanosine + Stavudine Contraindicated
- Allopurinol + Didanosine Major
- Atidarsagene autotemcel + Didanosine Major
Frequently asked questions
Can I take Didanosine with Doxycycline?
MediHelp rates the interaction as moderate. Didanosine and Doxycycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Buffered didanosine formulations contain magnesium and aluminium antacids that bind doxycycline in the gut. Absorption of doxycycline falls, which may compromise treatment.
How serious is the interaction between Didanosine and Doxycycline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give doxycycline at least 2 hours before buffered didanosine, or use a non-chelating alternative.
What other medicines interact with Doxycycline?
MediHelp also lists interactions of Doxycycline with, for example, Acitretin, Aminolevulinic acid, Cholera vaccine. The full list is on the Doxycycline page.
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