Drug interactions
Didanosine + Levofloxacin
Severity: Moderate
Didanosine and Levofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buffered didanosine formulations contain aluminum and magnesium that bind levofloxacin and reduce its absorption. This may lower antibiotic exposure and risk treatment failure.
What this interaction means in plain words
Didanosine and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Didanosine belongs to Anti Virals; Levofloxacin belongs to Anti Bacterial.
Why it happens
Chelation of levofloxacin by polyvalent cations in buffered didanosine, reducing gastrointestinal absorption.
What to do
Give levofloxacin at least 2 hours before the buffered didanosine formulation. Do not give it shortly after the didanosine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Other interactions of Didanosine
- Didanosine + Elvitegravir / cobicistat / emtricitabine / tenofovir df Contraindicated
- Didanosine + Hydroxycarbamide Contraindicated
- Didanosine + Ribavirin Contraindicated
- Didanosine + Stavudine Contraindicated
- Allopurinol + Didanosine Major
- Atidarsagene autotemcel + Didanosine Major
Frequently asked questions
Can I take Didanosine with Levofloxacin?
MediHelp rates the interaction as moderate. Didanosine and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Buffered didanosine formulations contain aluminum and magnesium that bind levofloxacin and reduce its absorption. This may lower antibiotic exposure and risk treatment failure.
How serious is the interaction between Didanosine and Levofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give levofloxacin at least 2 hours before the buffered didanosine formulation. Do not give it shortly after the didanosine dose.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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