Drug interactions
Didanosine + Levothyroxine
Severity: Moderate
Didanosine and Levothyroxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buffered didanosine formulations contain antacid agents that may bind levothyroxine and raise gastric pH, reducing its absorption. This can lead to reduced thyroid hormone effect and rising TSH.
What this interaction means in plain words
Didanosine and Levothyroxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Didanosine belongs to Anti Virals; Levothyroxine belongs to Endocrine.
Why it happens
Antacid buffers in didanosine bind levothyroxine and alter gastric pH, reducing absorption.
What to do
Separate levothyroxine from buffered didanosine by at least 4 hours, and monitor TSH.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Didanosine
- Didanosine + Elvitegravir / cobicistat / emtricitabine / tenofovir df Contraindicated
- Didanosine + Hydroxycarbamide Contraindicated
- Didanosine + Ribavirin Contraindicated
- Didanosine + Stavudine Contraindicated
- Allopurinol + Didanosine Major
- Atidarsagene autotemcel + Didanosine Major
Other interactions of Levothyroxine
Frequently asked questions
Can I take Didanosine with Levothyroxine?
MediHelp rates the interaction as moderate. Didanosine and Levothyroxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Buffered didanosine formulations contain antacid agents that may bind levothyroxine and raise gastric pH, reducing its absorption. This can lead to reduced thyroid hormone effect and rising TSH.
How serious is the interaction between Didanosine and Levothyroxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate levothyroxine from buffered didanosine by at least 4 hours, and monitor TSH.
What other medicines interact with Didanosine?
MediHelp also lists interactions of Didanosine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Hydroxycarbamide, Ribavirin. The full list is on the Didanosine page.
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